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>   home   >   Products   >   Primary Antibodies   >   SUV4-20H2 Antibody (N-term)   

SUV4-20H2 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SUV4-20H2 Antibody (N-term) AP12073a
    SUV4-20H2 Antibody (N-term) (Cat. #AP12073a) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the SUV4-20H2 antibody detected the SUV4-20H2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q86Y97
Other Accession NP_116090.2
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 52113 Da
Antigen Region 60-99 aa
Additional Information
Gene ID 84787
Other Names Histone-lysine N-methyltransferase SUV420H2, Lysine N-methyltransferase 5C, Suppressor of variegation 4-20 homolog 2, Su(var)4-20 homolog 2, Suv4-20h2, SUV420H2, KMT5C
Target/Specificity This SUV4-20H2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-90 amino acids of human SUV4-20H2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSUV4-20H2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KMT5C (HGNC:28405)
Synonyms SUV420H2
Function Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity).
Cellular Location Nucleus. Chromosome. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity).
Citations (0)

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SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).


Stolk, L., et al. Nat. Genet. (2009) In press :
Souza, P.P., et al. BMC Cell Biol. 10, 41 (2009) :
Yang, H., et al. J. Biol. Chem. 283(18):12085-12092(2008)
Szafranski, K., et al. Genome Biol. 8 (8), R154 (2007) :
Tryndyak, V.P., et al. Cancer Biol. Ther. 5(1):65-70(2006)

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$ 325.00
$ 109.00
Cat# AP12073a
Availability: In Stock
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