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ZFYVE1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9HBF4 |
| Other Accession | Q810J8, NP_848535.1, NP_067083.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 87176 Da |
| Antigen Region | 145-173 aa |
| Gene ID | 53349 |
|---|---|
| Other Names | Zinc finger FYVE domain-containing protein 1, Double FYVE-containing protein 1, SR3, Tandem FYVE fingers-1, ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1 |
| Target/Specificity | This ZFYVE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-173 amino acids from the N-terminal region of human ZFYVE1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZFYVE1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZFYVE1 |
|---|---|
| Synonyms | DFCP1, KIAA1589, TAFF1, ZNFN2A1 |
| Function | Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:30970241). Regulates the morphology, size and distribution of LDs (PubMed:31293035, PubMed:30970241). Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts by forming a complex with RAB18 and ZW10 (PubMed:30970241). Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (PubMed:11739631, PubMed:11256955). |
| Cellular Location | Golgi apparatus, Golgi stack. Golgi apparatus. Endoplasmic reticulum. Lipid droplet Preautophagosomal structure Mitochondrion. Note=Resides predominantly in the cisternal stacks of the Golgi (PubMed:11256955). Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum (PubMed:22178386) During starvation conditions, localizes to omegasomes which are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures (PubMed:31293035, PubMed:25876663) Localizes to lipid droplets in the presence of oleic acid (PubMed:31293035, PubMed:30970241). |
| Tissue Location | [Isoform 2]: Highly expressed in heart. Also detected in the testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate (PtdIns(3)P)-containing membranes. This gene encodes a protein which contains two zinc-binding FYVE domains in tandem. This protein displays a predominantly Golgi, endoplasmic reticulum and vesicular distribution. Alternatively spliced transcript variants have been found for this gene, and they encode two isoforms with different sizes.
References
Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)
Heilig, R., et al. Nature 421(6923):601-607(2003)
Krugmann, S., et al. Mol. Cell 9(1):95-108(2002)
Ridley, S.H., et al. J. Cell. Sci. 114 (PT 22), 3991-4000 (2001) :
Cheung, P.C., et al. Biochem. J. 355 (PT 1), 113-121 (2001) :
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