HOXB3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | P14651 |
Other Accession | NP_002137.4 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 44340 Da |
Antigen Region | 119-148 aa |
Gene ID | 3213 |
---|---|
Other Names | Homeobox protein Hox-B3, Homeobox protein Hox-27, Homeobox protein Hox-2G, HOXB3, HOX2G |
Target/Specificity | This HOXB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 119-148 amino acids from the Central region of human HOXB3. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | HOXB3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | HOXB3 |
---|---|
Synonyms | HOX2G |
Function | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML).
References
Palakurthy, R.K., et al. Mol. Cell 36(2):219-230(2009)
Ferrai, C., et al. Mol. Biol. Cell 20(15):3543-3551(2009)
Chung, N., et al. Mol. Biol. Rep. 36(2):227-235(2009)
Speleman, F., et al. Leukemia 19(3):358-366(2005)
Roche, J., et al. Leukemia 18(6):1059-1063(2004)
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