GMPR Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | P36959 |
Other Accession | NP_006868.3 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 37419 Da |
Antigen Region | 238-267 aa |
Gene ID | 2766 |
---|---|
Other Names | GMP reductase 1, Guanosine 5'-monophosphate oxidoreductase 1, Guanosine monophosphate reductase 1, GMPR, GMPR1 |
Target/Specificity | This GMPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 238-267 amino acids from the C-terminal region of human GMPR. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GMPR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GMPR |
---|---|
Synonyms | GMPR1 {ECO:0000255|HAMAP-Rule:MF_03195} |
Function | Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides.
References
Chasman, D.I., et al. PLoS Genet. 5 (11), E1000730 (2009) :
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Deng, Y., et al. Int. J. Biochem. Cell Biol. 34(9):1035-1050(2002)
Salvatore, D., et al. J. Biol. Chem. 273(47):31092-31096(1998)
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