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TRAPPC2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P0DI81 |
| Other Accession | F1SRI0, Q9CQP2, Q08CN0, Q5ZKP4, Q3T0F2, P0DI82 |
| Reactivity | Human |
| Predicted | Bovine, Chicken, Zebrafish, Mouse, Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 16445 Da |
| Antigen Region | 11-39 aa |
| Gene ID | 6399 |
|---|---|
| Other Names | Trafficking protein particle complex subunit 2, Sedlin, TRAPPC2, SEDL |
| Target/Specificity | This TRAPPC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-39 amino acids from the N-terminal region of human TRAPPC2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRAPPC2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRAPPC2 |
|---|---|
| Synonyms | SEDL |
| Function | Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi. |
| Cellular Location | Cytoplasm, perinuclear region. Endoplasmic reticulum-Golgi intermediate compartment. Nucleus. Cytoplasm. Note=Localized in perinuclear granular structures. |
| Tissue Location | Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, fetal cartilage, fibroblasts, placenta and lymphocytes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
TRAPPC2 is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseudogenes are found on chromosomes 8 and Y.
References
Liu, X., et al. J. Cell. Biochem. 109(6):1129-1133(2010)
Jeyabalan, J., et al. PLoS ONE 5 (5), E10646 (2010) :
Xia, X.Y., et al. Clin. Chim. Acta 410 (1-2), 39-42 (2009) :
Guo, H., et al. J. Genet. 88(1):87-91(2009)
Xiong, F., et al. Eur. J. Hum. Genet. 17(4):510-516(2009)
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