|Application ||WB, FC, E|
|Other Accession||Q7TPD0, Q5RE70|
|Calculated MW||118070 Da|
|Other Names||Integrator complex subunit 3, Int3, SOSS complex subunit A, Sensor of single-strand DNA complex subunit A, SOSS-A, Sensor of ssDNA subunit A, INTS3, C1orf193, C1orf60|
|Target/Specificity||This INTS3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 518-551 amino acids from the Central region of human INTS3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||INTS3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).|
|Cellular Location||Nucleus. Cytoplasm. Note=Localizes to nuclear foci following DNA damage|
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Provided below are standard protocols that you may find useful for product applications.
Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Baillat D.,et al.Cell 123:265-276(2005).
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