- CITATIONS: 2
|Application ||WB, IHC-P, E|
|Calculated MW||14522 Da|
|Antigen Region||76-105 aa|
|Other Names||Shadow of prion protein, Protein shadoo, SPRN, SHO|
|Target/Specificity||This SPRN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-105 amino acids from the C-terminal region of human SPRN.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SPRN Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity).|
|Cellular Location||Cell membrane; Lipid-anchor, GPI- anchor|
|Tissue Location||Mainly expressed in brain. In brain, it is expressed in hippocampus.|
Provided below are standard protocols that you may find useful for product applications.
SPRN has PrP(C)-like neuroprotective activity. SPRN may act as a modulator for the biological actions of normal and abnormal PrP.
Beck, J.A., et al. J. Med. Genet. 45(12):813-817(2008)
Van den Brulle, J., et al. BioTechniques 45(3):340-343(2008)
Premzl, M., et al. Mol. Biol. Evol. 21(12):2210-2231(2004)
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