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FAM92A1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | A1XBS5 |
| Other Accession | Q3SZG6 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 33431 Da |
| Antigen Region | 113-141 aa |
| Gene ID | 137392 |
|---|---|
| Other Names | Protein FAM92A1, FAM92A1 |
| Target/Specificity | This FAM92A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-141 amino acids from the Central region of human FAM92A1. |
| Dilution | IHC-P~~1:50~100 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FAM92A1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CIBAR1 (HGNC:30452) |
|---|---|
| Synonyms | FAM92A, FAM92A1 |
| Function | Plays a critical role in regulating mitochondrial ultrastructure and function by maintaining the integrity of mitochondrial morphology, particularly the organization of cristae (PubMed:30404948). Preferentially binds to negatively charged phospholipids like cardiolipin and phosphatidylinositol 4,5- bisphosphate enhancing its interaction with mitochondrial membranes (PubMed:30404948). Induces membrane curvature and tubulation, which are critical for maintaining mitochondrial ultrastructure and the organization of cristae (PubMed:30404948). Plays a crucial role in ciliogenesis (PubMed:27528616, PubMed:30395363). May play a role in limb development through its role in ciliogenesis (PubMed:30395363). Plays a key role in the correct positioning of the annulus, a septin- based ring structure in the sperm flagellum, serving both as a physical barrier and a membrane diffusion barrier that separates the midpiece (MP) from the principal piece (PP) (By similarity). This positioning is essential for proper sperm motility and function (By similarity). Interacts with CBY3 to form a complex which localizes to the curved membrane region of the flagellar pocket (By similarity). By doing so, may provide stability and rigidity to the periannular membrane to prevent membrane deformation (By similarity). This function is crucial for halting annulus migration at the proximal end of the fibrous sheath-containing PP (By similarity). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium {ECO:0000250|UniProtKB:Q8BP22}. Nucleus. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q8BP22}. Note=Weak punctate vesicular distribution throughout the cytoplasm (PubMed:27528616). Localizes at the distal end of mother centrioles (PubMed:27528616). Extensive colocalization with CBY1 at mother centrioles (PubMed:27528616) Localizes to the annulus at the junction between the midpiece (MP) and principal piece (PP) of the sperm flagellum (By similarity) {ECO:0000250|UniProtKB:Q8BP22, ECO:0000269|PubMed:27528616} |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
The function of this protein has not been specifically defined.
References
Liang, S., et al. Cancer Lett. 276(1):81-87(2009)
Ruan, X.Z., et al. Mol. Cells 23(3):391-397(2007)
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$ 385.00
$ 150.00
Cat# AP5171c
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