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ZMYND11 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ZMYND11 Antibody (N-term) AP8592a
    Western blot analysis of ZMYND11 Antibody (N-term) (Cat. #AP8592a) in mouse brain tissue lysates (35ug/lane). ZMYND11 (arrow) was detected using the purified Pab.
    detail
  • IHC-P - ZMYND11 Antibody (N-term) AP8592a
    Formalin-fixed and paraffin-embedded H.colon tissue reacted with ZMYND11 Antibody (N-term) (Cat#AP8592a).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q15326
Other Accession Q8R5C8
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 70963 Da
Antigen Region 152-180 aa
Additional Information
Gene ID 10771
Other Names Zinc finger MYND domain-containing protein 11, Adenovirus 5 E1A-binding protein, Bone morphogenetic protein receptor-associated molecule 1, Protein BS69, ZMYND11, BRAM1, BS69
Target/Specificity This ZMYND11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 152-180 amino acids from the N-terminal region of human ZMYND11.
Dilution WB~~1:1000
IHC-P~~1:200
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsZMYND11 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZMYND11 (HGNC:16966)
Function Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth.
Cellular Location Nucleus. Chromosome Note=Associates with chromatin and mitotic chromosomes
Tissue Location Ubiquitous..
Research Areas
Citations (0)
citation

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Background

ZMYND11 is first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression.

References

Yu,B., Shao,Y., et.al., Exp. Cell Res. 315 (20), 3543-3553 (2009)
Kurozumi,K., et.al., Genes Cells 3 (4), 257-264 (1998)

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$ 182.50
$ 70.00
Cat# AP8592a
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