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ADAMTS18 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ADAMTS18 Antibody (C-term) AP8906B
    Western blot analysis of ADAMTS18 Antibody (C-term) (Cat. #AP8906b) in mouse liver tissue lysates (35ug/lane). ADAMTS18 (arrow) was detected using the purified Pab.
    detail
  • WB - ADAMTS18 Antibody (C-term) AP8906B
    ADAMTS18 Antibody (C-term) (Cat. #AP8906b) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the ADAMTS18 antibody detected the ADAMTS18 protein (arrow).
    detail
  • IHC-P - ADAMTS18 Antibody (C-term) AP8906B
    Formalin-fixed and paraffin-embedded human brain tissue reacted with ADAMTS18 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
    detail
  • FC - ADAMTS18 Antibody (C-term) AP8906B
    ADAMTS18 Antibody (C-term) (Cat. #AP8906b) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
  • SPECIFICATION
  • CITATIONS: 2
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, WB, IHC-P, E
Primary Accession Q8TE60
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 135167 Da
Antigen Region 1066-1095 aa
Additional Information
Gene ID 170692
Other Names A disintegrin and metalloproteinase with thrombospondin motifs 18, ADAM-TS 18, ADAM-TS18, ADAMTS-18, 3424-, ADAMTS18, ADAMTS21
Target/Specificity This ADAMTS18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1066-1095 amino acids from the C-terminal region of human ADAMTS18.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsADAMTS18 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADAMTS18
Synonyms ADAMTS21
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Expressed in fetal lung, liver, and kidney and in adult brain, prostate, submaxillary gland, and endothelium
Research Areas
Citations ( 0 )

Background

ADAMTS18 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This protein has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor.

References

Zeng,W., et.al., Biochim. Biophys. Acta 1760 (3), 517-524 (2006)
Jin,H., et.al., Oncogene 26 (53), 7490-7498 (2007)

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$ 365.00
$ 140.00
Cat# AP8906B
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