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UTY Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | O14607 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 149548 Da |
| Antigen Region | 1247-1276 aa |
| Gene ID | 7404 |
|---|---|
| Other Names | Histone demethylase UTY, 11411-, Ubiquitously-transcribed TPR protein on the Y chromosome, Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein, UTY, KDM6C |
| Target/Specificity | This UTY antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1247-1276 amino acids from the C-terminal region of human UTY. |
| Dilution | WB~~1:1000 IF~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | UTY Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UTY |
|---|---|
| Synonyms | KDM6C |
| Function | Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity. |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
UTY encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein-protein interactions. This protein is a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts.
References
Russo,P., et.al., Arterioscler. Thromb. Vasc. Biol. 28 (8), 1569-1574 (2008)
Gerrard,D.T. et.al., Mol. Biol. Evol. 22 (6), 1423-1432 (2005)
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