SELT Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, WB, E |
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Primary Accession | P62341 |
Other Accession | Q1H5H1, P62342, Q5ZJN8, A6QP01 |
Reactivity | Human |
Predicted | Bovine, Chicken, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 22324 Da |
Antigen Region | 48-75 aa |
Gene ID | 51714 |
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Other Names | Selenoprotein T, SelT, SELT |
Target/Specificity | This SELT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-75 amino acids from the N-terminal region of human SELT. |
Dilution | WB~~1:1000 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SELT Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SELENOT {ECO:0000303|PubMed:27645994, ECO:0000312|HGNC:HGNC:18136} |
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Function | Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress and cell death (PubMed:26866473). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP- induced insulin secretion (By similarity). |
Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q1H5H1}; Single-pass membrane protein |
Tissue Location | Ubiquitous. Highly expressed in the endocrine pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SELT encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
References
Kryukov,G.V., et.al., Science 300 (5624), 1439-1443 (2003)
Kryukov,G.V., et.al., J. Biol. Chem. 274 (48), 33888-33897 (1999)
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