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p90 RSK1 Antibody

     
  • ICC/IF - p90 RSK1 Antibody ASM10400
    Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-p90 RSK1 Polyclonal Antibody (ASM10400). Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-p90 RSK1 Polyclonal Antibody (ASM10400) at 1:50 for 12 hours at 4°C. Secondary Antibody: R-PE Goat Anti-Rabbit (yellow) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Nucleus. Cytoplasm. Magnification: 100x. (A) DAPI (blue) nuclear stain. (B) Anti-p90 RSK1 Antibody. (C) Composite. Heat Shocked at 42°C for 30 min.
  • WB - p90 RSK1 Antibody ASM10400
    Western blot analysis of Mouse brain cell lysates showing detection of RSK1 protein using Rabbit Anti-RSK1 Polyclonal Antibody (ASM10400). Primary Antibody: Rabbit Anti-RSK1 Polyclonal Antibody (ASM10400) at 1:1000. P90 RSK1 immuno-precipitated from the mouse brain extract (left) and immuno-precipitated negative control (right).
  • ICC/IF - p90 RSK1 Antibody ASM10400
    Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-p90 RSK1 Polyclonal Antibody (ASM10400). Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-p90 RSK1 Polyclonal Antibody (ASM10400) at 1:50 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Rabbit (green) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Nucleus. Cytoplasm. Magnification: 20x. (A) DAPI (blue) nuclear stain. (B) Anti-p90 RSK1 Antibody. (C) Composite. Heat Shocked at 42°C for 30 min.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IP, ICC/IF
Primary Accession Q15418
Other Accession NP_002944.2
Host Rabbit
Reactivity Human, Mouse, Rat, Bovine
Clonality Polyclonal
Description Rabbit Anti-Human p90 RSK1 Polyclonal
Target/Specificity Detects ~90kDa.
Other Names RSK1 p90 Antibody, HU1 Antibody, MAPKAP Antibody, p90rsk Antibody, p90S6K Antibody, RSK1 Antibody, RSK 1 p90 Antibody
Immunogen Human p90 RSK1 C-terminal peptide, conjugated to KLH
Purification Protein A Purified
Storage -20ºC
Storage Buffer TBS, 50% glycerol, 0.09% sodium azide
Shipping Temperature Blue Ice or 4ºC
Certificate of Analysis 0.25 mg/ml was sufficient for detection of SPC-147 in lysates prepared from mouse brain, spleen and intestine.
Cellular Localization Cytoplasm | Nucleus
Research Areas
Citations (0)

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Background

The p90 ribosomal S6 kinase (Rsk) family comprises four mammalian serine/threonine kinases (Rsk1–4). In the past, S6K1 and S6K2 were thought to be the predominant operating S6 kinases, however RSK 1 and 2 have been shown to phosphorylate S6 in response to the ERK pathway, or otherwise known as the extra cellular signal-regulated kinases pathway. RSK 1 in particular is very multifunctional as it participates in nuclear signaling, regulates nuclear factors, regulates several transcription factors like c-Fos, and interacts with the transcriptional coactivator CREB-binding protein. As a result, RSK1 seems to have an important role in cellular growth control and proliferation. (1-5).

References

1. Roux, P. (2007). UCSD-Nature Molecule Pages.
2. Fro¨din, M. and Gammeltoft, S. (1999) Mol. Cell. Endocrinol. 151: 65-77.
3. Merienne, K. et al. (1998) J. Med. Genet. 35: 890-894.
4. De Cesare, D. et al. (1998) Proc. Natl. Acad. Sci. 95: 12202-12207.
5. Joel, P. B. et al. (1998) Mol. Cell. Biol. 18: 1978-1984.

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Cat# ASM10400
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