ALG12 Antibody (monoclonal) (M06)
Mouse monoclonal antibody raised against a partial recombinant ALG12.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9BV10 |
Other Accession | NM_024105 |
Reactivity | Human, Rat |
Host | mouse |
Clonality | Monoclonal |
Isotype | IgG1 Kappa |
Clone Names | 5E4 |
Calculated MW | 54655 Da |
Gene ID | 79087 |
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Other Names | Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1, 6-mannosyltransferase, Asparagine-linked glycosylation protein 12 homolog, hALG12, Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1, 6-mannosyltransferase, Mannosyltransferase ALG12 homolog, Membrane protein SB87, ALG12 |
Target/Specificity | ALG12 (NP_077010, 369 a.a. ~ 425 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
Dilution | WB~~1:500~1000 |
Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
Precautions | ALG12 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the glycosyltransferase 22 family. The encoded protein catalyzes the addition of the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation. Mutations in this gene have been associated with congenital disorder of glycosylation type Ig (CDG-Ig)characterized by abnormal N-glycosylation.
References
Large-scale cDNA transfection screening for genes related to cancer development and progression. Wan D, et al. Proc Natl Acad Sci U S A, 2004 Nov 2. PMID 15498874.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.A genome annotation-driven approach to cloning the human ORFeome. Collins JE, et al. Genome Biol, 2004. PMID 15461802.Congenital disorders of glycosylation: a booming chapter of pediatrics. Jaeken J, et al. Curr Opin Pediatr, 2004 Aug. PMID 15273506.Congenital disorders of glycosylation (CDG): update and new developments. Jaeken J. J Inherit Metab Dis, 2004. PMID 15272470.
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