BACH1 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant BACH1.
|Application ||WB, E|
|Calculated MW||81958 Da|
|Other Names||Transcription regulator protein BACH1, BTB and CNC homolog 1, HA2303, BACH1|
|Target/Specificity||BACH1 (NP_996749, 396 a.a. ~ 492 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||BACH1 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene.
Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1. Miyazaki T, et al. Cancer Sci, 2010 Jun. PMID 20345481.BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control. Gong Z, et al. Mol Cell, 2010 Feb 12. PMID 20159562.MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins. Hou W, et al. Hepatology, 2010 May. PMID 20127796.A role for Bach1 and HO-2 in suppression of basal and UVA-induced HO-1 expression in human keratinocytes. Zhong JL, et al. Free Radic Biol Med, 2010 Jan 15. PMID 19874887.Prolonged cigarette smoke exposure decreases heme oxygenase-1 and alters Nrf2 and Bach1 expression in human macrophages: roles of the MAP kinases ERK(1/2) and JNK. Goven D, et al. FEBS Lett, 2009 Nov 3. PMID 19822148.
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