BAIAP2L1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant BAIAP2L1.
|Application ||WB, IHC, E|
|Calculated MW||56883 Da|
|Other Names||Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1, BAI1-associated protein 2-like protein 1, Insulin receptor tyrosine kinase substrate, BAIAP2L1, IRTKS|
|Target/Specificity||BAIAP2L1 (NP_061330, 398 a.a. ~ 511 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||BAIAP2L1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation.
Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. Voss M, et al. BMC Immunol, 2009 Oct 6. PMID 19807924.Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation. Vingadassalom D, et al. Proc Natl Acad Sci U S A, 2009 Apr 21. PMID 19366662.IRSp53: crossing the road of membrane and actin dynamics in the formation of membrane protrusions. Scita G, et al. Trends Cell Biol, 2008 Feb. PMID 18215522.Distinctive gene expression signatures in rheumatoid arthritis synovial tissue fibroblast cells: correlates with disease activity. Galligan CL, et al. Genes Immun, 2007 Sep. PMID 17568789.Characterisation of IRTKS, a novel IRSp53/MIM family actin regulator with distinct filament bundling properties. Millard TH, et al. J Cell Sci, 2007 May 1. PMID 17430976.
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