BZRP Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant BZRP.
|Application ||WB, E|
|Calculated MW||18828 Da|
|Other Names||Translocator protein, Mitochondrial benzodiazepine receptor, PKBS, Peripheral-type benzodiazepine receptor, PBR, TSPO, BZRP, MBR|
|Target/Specificity||BZRP (AAH01110.1, 1 a.a. ~ 169 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||BZRP Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Oral cancer, cigarette smoke and mitochondrial 18kDa translocator protein (TSPO) - In vitro, in vivo, salivary analysis. Nagler R, et al. Biochim Biophys Acta, 2010 May. PMID 20085808.The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals. Costa B, et al. Endocrinology, 2009 Dec. PMID 19846611.Translocator protein blockade reduces prostate tumor growth. Fafalios A, et al. Clin Cancer Res, 2009 Oct 1. PMID 19789311.Genetic susceptibility to distinct bladder cancer subphenotypes. Guey LT, et al. Eur Urol, 2010 Feb. PMID 19692168.Ala147Thr substitution in translocator protein is associated with adult separation anxiety in patients with depression. Costa B, et al. Psychiatr Genet, 2009 Apr. PMID 19668118.
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