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CLDN2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant CLDN2.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P57739 |
| Other Accession | NM_020384 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 3F1 |
| Calculated MW | 24549 Da |
| Gene ID | 9075 |
|---|---|
| Other Names | Claudin-2, SP82, CLDN2 |
| Target/Specificity | CLDN2 (NP_065117, 29 a.a. ~ 80 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CLDN2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.
References
1.A novel microfluidics-based method for probing weak protein-protein interactions.Tan DC, Wijay IP, Ochsner M, Vasina EN, Nallani M, Hunziker W, Kathrin-Sinner E.Lab Chip, 2012 DOI: 10.1039/C2LC40228A2.Proteopolymersomes: In vitro production of a membrane protein in polymersome membranes.Nallani M, Andreasson-Ochsner M, Darren Tan CW, Sinner EK, Wisantoso Y, Geifman-Shochat S, Hunziker W.Biointerphases 6, 153 (2011); doi:10.1116/ 1.36443843.Probing Effects of pH change on Dynamic Response of Claudin-2 Mediated Adhesion Using Single Molecule Force Spectroscopy.Lim TS, Vedula SR, Huic S, Kausalya PJ, Hunzikerd W, Lim CT.Exp Cell Res. 2008 Aug 15;314(14):2643-51. Epub 2008 Jun 3.
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