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CLDN20 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant CLDN20.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | P56880 |
| Other Accession | BC020838 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 4E7 |
| Calculated MW | 23515 Da |
| Gene ID | 49861 |
|---|---|
| Other Names | Claudin-20, CLDN20 |
| Target/Specificity | CLDN20 (AAH20838, 1 a.a. ~ 219 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CLDN20 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions.
References
The claudins. Lal-Nag M, et al. Genome Biol, 2009. PMID 19706201.Biology of claudins. Angelow S, et al. Am J Physiol Renal Physiol, 2008 Oct. PMID 18480174.Structure and function of claudins. Krause G, et al. Biochim Biophys Acta, 2008 Mar. PMID 18036336.Analysis of the RPE transcriptome reveals dynamic changes during the development of the outer blood-retinal barrier. Rizzolo LJ, et al. Mol Vis, 2007 Jul 23. PMID 17679949.The claudin gene family: expression in normal and neoplastic tissues. Hewitt KJ, et al. BMC Cancer, 2006 Jul 12. PMID 16836752.
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