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COASY Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a partial recombinant COASY.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | Q13057 |
| Other Accession | NM_025233 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 2A12 |
| Calculated MW | 62329 Da |
| Gene ID | 80347 |
|---|---|
| Other Names | Bifunctional coenzyme A synthase, CoA synthase, NBP, POV-2, Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT, Dephospho-CoA kinase, DPCK, Dephosphocoenzyme A kinase, DPCOAK, COASY |
| Target/Specificity | COASY (NP_079509, 461 a.a. ~ 564 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | COASY Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. COASY is a bifunctional enzyme that catalyzes the 2 last steps in CoA synthesis. These activities are performed by 2 separate enzymes, phosphopantetheine adenylyltransferase (PPAT; EC 2.7.7.3) and dephospho-CoA kinase (DPCK; EC 2.7.1.24), in prokaryotes (Daugherty et al., 2002 [PubMed 11923312]).
References
Genetic susceptibility to distinct bladder cancer subphenotypes. Guey LT, et al. Eur Urol, 2010 Feb. PMID 19692168.CoA synthase is in complex with p85alphaPI3K and affects PI3K signaling pathway. Breus O, et al. Biochem Biophys Res Commun, 2009 Aug 7. PMID 19482007.Possible difference in frequencies of genetic polymorphisms of estrogen receptor alpha, estrogen metabolism and P53 genes between estrogen receptor-positive and -negative breast cancers. Hamaguchi M, et al. Jpn J Clin Oncol, 2008 Nov. PMID 18820009.Identification of a novel CoA synthase isoform, which is primarily expressed in the brain. Nemazanyy I, et al. Biochem Biophys Res Commun, 2006 Mar 24. PMID 16460672.Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.
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