CUL7 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant CUL7.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q14999 |
Other Accession | BC033647 |
Reactivity | Human |
Host | mouse |
Clonality | Monoclonal |
Isotype | IgG1 kappa |
Clone Names | 2G11 |
Calculated MW | 191161 Da |
Gene ID | 9820 |
---|---|
Other Names | Cullin-7, CUL-7, CUL7, KIAA0076 |
Target/Specificity | CUL7 (AAH33647, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
Dilution | WB~~1:500~1000 |
Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
Precautions | CUL7 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene.
References
Cullins in human intra-uterine growth restriction: expressional and epigenetic alterations. Gascoin-Lachambre G, et al. Placenta, 2010 Feb. PMID 20005570.A large-scale mutation search reveals genetic heterogeneity in 3M syndrome. Huber C, et al. Eur J Hum Genet, 2009 Mar. PMID 19225462.CUL7 is a novel antiapoptotic oncogene. Kim SS, et al. Cancer Res, 2007 Oct 15. PMID 17942889.Clinical, molecular and histopathological features of short stature syndrome with novel CUL7 mutation in Yakuts: new population isolate in Asia. Maksimova N, et al. J Med Genet, 2007 Dec. PMID 17675530.Induction of cullin 7 by DNA damage attenuates p53 function. Jung P, et al. Proc Natl Acad Sci U S A, 2007 Jul 3. PMID 17586686.
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