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CUL7 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant CUL7.

     
  • WB - CUL7 Antibody (monoclonal) (M01) AT1683a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) .
    detail
  • E - CUL7 Antibody (monoclonal) (M01) AT1683a
    Detection limit for recombinant GST tagged CUL7 is approximately 0.03ng/ml as a capture antibody.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q14999
Other Accession BC033647
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 kappa
Clone Names 2G11
Calculated MW 191161 Da
Additional Information
Gene ID 9820
Other Names Cullin-7, CUL-7, CUL7, KIAA0076
Target/Specificity CUL7 (AAH33647, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsCUL7 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene.

References

Cullins in human intra-uterine growth restriction: expressional and epigenetic alterations. Gascoin-Lachambre G, et al. Placenta, 2010 Feb. PMID 20005570.A large-scale mutation search reveals genetic heterogeneity in 3M syndrome. Huber C, et al. Eur J Hum Genet, 2009 Mar. PMID 19225462.CUL7 is a novel antiapoptotic oncogene. Kim SS, et al. Cancer Res, 2007 Oct 15. PMID 17942889.Clinical, molecular and histopathological features of short stature syndrome with novel CUL7 mutation in Yakuts: new population isolate in Asia. Maksimova N, et al. J Med Genet, 2007 Dec. PMID 17675530.Induction of cullin 7 by DNA damage attenuates p53 function. Jung P, et al. Proc Natl Acad Sci U S A, 2007 Jul 3. PMID 17586686.

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$ 350.00
Cat# AT1683a
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Availability: 7-10 days
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