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DNAI1 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a full length recombinant DNAI1.

     
  • WB - DNAI1 Antibody (monoclonal) (M01) AT1785a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (102.63 KDa) .
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9UI46
Other Accession BC030583
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a kappa
Clone Names 2D10-2A5
Calculated MW 79283 Da
Additional Information
Gene ID 27019
Other Names Dynein intermediate chain 1, axonemal, Axonemal dynein intermediate chain 1, DNAI1
Target/Specificity DNAI1 (AAH30583, 1 a.a. ~ 699 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsDNAI1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
citation

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Background

The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia (PCD) and Kartagener syndrome.

References

Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Primary ciliary dyskinesia: improving the diagnostic approach. Leigh MW, et al. Curr Opin Pediatr, 2009 Jun. PMID 19300264.Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia. Zuccarello D, et al. Hum Reprod, 2008 Aug. PMID 18492703.DNAI1 mutations explain only 2% of primary ciliary dykinesia. Failly M, et al. Respiration, 2008. PMID 18434704.Mutations of DNAI1 in primary ciliary dyskinesia: evidence of founder effect in a common mutation. Zariwala MA, et al. Am J Respir Crit Care Med, 2006 Oct 15. PMID 16858015.

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$ 350.00
Cat# AT1785a
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