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DPYS Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant DPYS.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q14117 |
| Other Accession | NM_001385 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 3B1 |
| Calculated MW | 56630 Da |
| Gene ID | 1807 |
|---|---|
| Other Names | Dihydropyrimidinase, DHP, DHPase, Dihydropyrimidine amidohydrolase, Hydantoinase, DPYS |
| Target/Specificity | DPYS (NP_001376, 422 a.a. ~ 519 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | DPYS Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.
References
Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT. Kim HY, et al. BMB Rep, 2010 Aug. PMID 20797317.Dihydropyrimidinase deficiency: Phenotype, genotype and structural consequences in 17 patients. van Kuilenburg AB, et al. Biochim Biophys Acta, 2010 Jul-Aug. PMID 20362666.Contribution of dihydropyrimidinase gene alterations to the development of serious toxicity in fluoropyrimidine-treated cancer patients. Fidlerova J, et al. Cancer Chemother Pharmacol, 2010 Mar. PMID 19649633.Genetic regulation of beta-ureidopropionase and its possible implication in altered uracil catabolism. Thomas HR, et al. Pharmacogenet Genomics, 2008 Jan. PMID 18216719.Genetic regulation of dihydropyrimidinase and its possible implication in altered uracil catabolism. Thomas HR, et al. Pharmacogenet Genomics, 2007 Nov. PMID 18075467.
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