DYM Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant DYM.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
---|---|
Primary Accession | Q7RTS9 |
Other Accession | NM_017653 |
Reactivity | Human |
Host | mouse |
Clonality | Monoclonal |
Isotype | IgG1 Kappa |
Clone Names | 1C2 |
Calculated MW | 75935 Da |
Gene ID | 54808 |
---|---|
Other Names | Dymeclin, Dyggve-Melchior-Clausen syndrome protein, DYM |
Target/Specificity | DYM (NP_060123, 343 a.a. ~ 430 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
Precautions | DYM Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein which is necessary for normal skeletal development and brain function. Mutations in this gene are associated with two types of recessive osteochondrodysplasia, Dyggve-Melchior-Clausen (DMC) dysplasia and Smith-McCort (SMC) dysplasia, which involve both skeletal defects and mental retardation.
References
An association study between the dymeclin gene and schizophrenia in the Japanese population. Yazaki S, et al. J Hum Genet, 2010 Sep. PMID 20555340.The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. Zhao J, et al. BMC Med Genet, 2010 Jun 14. PMID 20546612.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.The gene responsible for Dyggve-Melchior-Clausen syndrome encodes a novel peripheral membrane protein dynamically associated with the Golgi apparatus. Dimitrov A, et al. Hum Mol Genet, 2009 Feb 1. PMID 18996921.Genome-wide association analysis identifies 20 loci that influence adult height. Weedon MN, et al. Nat Genet, 2008 May. PMID 18391952.
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