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EBI3 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant EBI3. (Please notice that this antibo
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q14213 |
| Other Accession | NM_005755 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 1D3 |
| Calculated MW | 25396 Da |
| Gene ID | 10148 |
|---|---|
| Other Names | Interleukin-27 subunit beta, IL-27 subunit beta, IL-27B, Epstein-Barr virus-induced gene 3 protein, EBV-induced gene 3 protein, EBI3, IL27B |
| Target/Specificity | EBI3 (NP_005746, 129 a.a. ~ 229 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | EBI3 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells.
References
Epstein-barr virus-induced gene-3 is expressed in human atheroma plaques. Kempe S, et al. Am J Pathol, 2009 Jul. PMID 19556516.IL27: its roles in the induction and inhibition of inflammation. Carl JW, et al. Int J Clin Exp Pathol, 2008 Jan 1. PMID 18784808.Genome-wide analysis displays marked induction of EBI3/IL-27B in IL-18-activated AML-derived KG1 cells: critical role of two kappaB binding sites in the human EBI3 promotor. Poleganov MA, et al. Mol Immunol, 2008 May. PMID 18336908.Enhanced expression of IL-27 mRNA in human newborns. Krumbiegel D, et al. Pediatr Allergy Immunol, 2008 Sep. PMID 18167155.Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514.
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