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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   SDCBP monoclonal antibody (M01), clone 2C12   

SDCBP monoclonal antibody (M01), clone 2C12

Mouse monoclonal antibody raised against a partial recombinant SDCBP.

  • WB - SDCBP monoclonal antibody (M01), clone 2C12 AT3799a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .
  • WB - SDCBP monoclonal antibody (M01), clone 2C12 AT3799a
    SDCBP monoclonal antibody (M01), clone 2C12 Western Blot analysis of SDCBP expression in HepG2 ( (Cat # AT3799a )
  • WB - SDCBP monoclonal antibody (M01), clone 2C12 AT3799a
    Western Blot analysis of SDCBP expression in transfected 293T cell line by SDCBP monoclonal antibody (M01), clone 2C12.

    Lane 1: SDCBP transfected lysate(32.4 KDa).
    Lane 2: Non-transfected lysate.
  • IHC - SDCBP monoclonal antibody (M01), clone 2C12 AT3799a
    Immunoperoxidase of monoclonal antibody to SDCBP on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 3 ug/ml]
  • IF - SDCBP monoclonal antibody (M01), clone 2C12 AT3799a
    Immunofluorescence of monoclonal antibody to SDCBP on HepG2 cell. [antibody concentration 35 ug/ml]
  • IP - SDCBP monoclonal antibody (M01), clone 2C12 AT3799a
    Immunoprecipitation of SDCBP transfected lysate using anti-SDCBP monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with SDCBP MaxPab rabbit polyclonal antibody.
  • E - SDCBP monoclonal antibody (M01), clone 2C12 AT3799a
    Detection limit for recombinant GST tagged SDCBP is approximately 0.03ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O00560
Other Accession NM_005625
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 2C12
Calculated MW 32444 Da
Additional Information
Gene ID 6386
Other Names Syntenin-1, Melanoma differentiation-associated protein 9, MDA-9, Pro-TGF-alpha cytoplasmic domain-interacting protein 18, TACIP18, Scaffold protein Pbp1, Syndecan-binding protein 1, SDCBP, MDA9, SYCL
Target/Specificity SDCBP (NP_005616, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsSDCBP monoclonal antibody (M01), clone 2C12 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms.


1.Syntenin increases the invasiveness of small cell lung cancer cells by activating p38, AKT, focal adhesion kinase and SP1.Kim WY, Jang JY, Jeon YK, Chung DH, Kim YG, Kim CWExp Mol Med. 2014 Apr 11;46:e90. doi: 10.1038/emm.2014.1.2.Novel Role of MDA-9/Syntenin in Regulating Urothelial Cell Proliferation by Modulating EGFR Signaling.Dasgupta S, Menezes ME, Das SK, Emdad L, Janjic A, Bhatia S, Mukhopadhyay ND, Shao C, Sarkar D, Fisher PBClin Cancer Res. 2013 Sep 1;19(17):4621-33. doi: 10.1158/1078-0432.CCR-13-0585. Epub 2013 Jul 19.3.MDA-9/Syntenin and IGFBP-2 Promote Angiogenesis in Human Melanoma.Das SK, Bhutia SK, Azab B, Kegelman TP, Peachy L, Santhekadur PK, Dasgupta S, Dash R, Dent P, Grant S, Emdad L, Pellecchia M, Sarkar D, Fisher PB.Cancer Res. 2013 Jan 15;73(2):844-54. doi: 10.1158/0008-5472.CAN-12-1681. Epub 2012 Dec 10.4.Raf kinase inhibitor RKIP inhibits MDA-9/syntenin-mediated metastasis in melanoma.Das SK, Bhutia SK, Sokhi UK, Azab B, Su ZZ, Boukerche H, Anwar T, Moen EL, Chatterjee D, Pellecchia M, Sarkar D, Fisher PB.Cancer Res. 2012 Oct 11. [Epub ahead of print]5.Systematic proteomic analysis of human hepotacellular carcinoma cells reveals molecular pathways and networks involved in metastasis.Yu Y, Shen H, Yu H, Zhong F, Zhang Y, Zhang C, Zhao J, Li H, Chen J, Liu Y, Yang P.Mol Biosyst. 2011 Jun;7(6):1908-16. Epub 2011 Apr 6.

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Cat# AT3799a
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