SDCBP monoclonal antibody (M01), clone 2C12
Mouse monoclonal antibody raised against a partial recombinant SDCBP.
|Application ||WB, IHC, IF, IP|
|Calculated MW||32444 Da|
|Other Names||Syntenin-1, Melanoma differentiation-associated protein 9, MDA-9, Pro-TGF-alpha cytoplasmic domain-interacting protein 18, TACIP18, Scaffold protein Pbp1, Syndecan-binding protein 1, SDCBP, MDA9, SYCL|
|Target/Specificity||SDCBP (NP_005616, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||SDCBP monoclonal antibody (M01), clone 2C12 is for research use only and not for use in diagnostic or therapeutic procedures.|
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The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms.
1.Syntenin increases the invasiveness of small cell lung cancer cells by activating p38, AKT, focal adhesion kinase and SP1.Kim WY, Jang JY, Jeon YK, Chung DH, Kim YG, Kim CWExp Mol Med. 2014 Apr 11;46:e90. doi: 10.1038/emm.2014.1.2.Novel Role of MDA-9/Syntenin in Regulating Urothelial Cell Proliferation by Modulating EGFR Signaling.Dasgupta S, Menezes ME, Das SK, Emdad L, Janjic A, Bhatia S, Mukhopadhyay ND, Shao C, Sarkar D, Fisher PBClin Cancer Res. 2013 Sep 1;19(17):4621-33. doi: 10.1158/1078-0432.CCR-13-0585. Epub 2013 Jul 19.3.MDA-9/Syntenin and IGFBP-2 Promote Angiogenesis in Human Melanoma.Das SK, Bhutia SK, Azab B, Kegelman TP, Peachy L, Santhekadur PK, Dasgupta S, Dash R, Dent P, Grant S, Emdad L, Pellecchia M, Sarkar D, Fisher PB.Cancer Res. 2013 Jan 15;73(2):844-54. doi: 10.1158/0008-5472.CAN-12-1681. Epub 2012 Dec 10.4.Raf kinase inhibitor RKIP inhibits MDA-9/syntenin-mediated metastasis in melanoma.Das SK, Bhutia SK, Sokhi UK, Azab B, Su ZZ, Boukerche H, Anwar T, Moen EL, Chatterjee D, Pellecchia M, Sarkar D, Fisher PB.Cancer Res. 2012 Oct 11. [Epub ahead of print]5.Systematic proteomic analysis of human hepotacellular carcinoma cells reveals molecular pathways and networks involved in metastasis.Yu Y, Shen H, Yu H, Zhong F, Zhang Y, Zhang C, Zhao J, Li H, Chen J, Liu Y, Yang P.Mol Biosyst. 2011 Jun;7(6):1908-16. Epub 2011 Apr 6.
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