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GGH Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q92820 |
|---|---|
| Clone Names | 101008118 |
| Gene ID | 8836 |
|---|---|
| Other Names | Gamma-glutamyl hydrolase, Conjugase, GH, Gamma-Glu-X carboxypeptidase, GGH |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GGH (HGNC:4248) |
|---|---|
| Function | Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate (PubMed:11005824, PubMed:8816764). May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. |
| Cellular Location | Secreted, extracellular space. Lysosome. Melanosome. Note=While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene catalyzes the hydrolysis offolylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates bythe removal of gamma-linked polyglutamates and glutamate. [providedby RefSeq].
References
Adjei, A.A., et al. J Thorac Oncol 5(9):1346-1353(2010)Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Organista-Nava, J., et al. Leuk. Res. 34(6):728-732(2010)Figueiredo, J.C., et al. Cancer Causes Control 21(4):597-608(2010)Dervieux, T., et al. Pharmacogenet. Genomics (2009) In press :
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