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PRMT8 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9NR22
Clone Names 70411210
Additional Information
Gene ID 56341
Other Names Protein arginine N-methyltransferase 8, 211-, Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4, PRMT8, HRMT1L3, HRMT1L4
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1219b was selected from the C-term region of human PRMT8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRMT8 (HGNC:5188)
Synonyms HRMT1L3, HRMT1L4
Function S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein, histone H4, H2A and H2A/H2B dimer (PubMed:16051612, PubMed:17925405, PubMed:26876602, PubMed:26529540). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS (PubMed:18320585).
Cellular Location Cell membrane; Lipid-anchor; Cytoplasmic side
Tissue Location Brain-specific..
Research Areas
Citations (0)
citation

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Background

Protein arginine methylation plays a role in signal transduction, RNA processing, transcriptional regulation, and DNA repair. PRMT8, a protein arginine N-methyltransferase most closely related to PRMT1, methylates the guanidino nitrogens of arginyl residues in some proteins. This protein associates with the plasma membrane following myristoylation and exhibits a brain-specific expression pattern, making it unique within this family of enzymes.

References

Lee,J., J. Biol. Chem. 280 (38), 32890-32896 (2005)

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$ 277.78
Cat# BP1219b
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