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ARHG7 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q14155
Clone Names 80220172
Peptide ID 80220172
Additional Information
Gene ID 8874
Other Names Rho guanine nucleotide exchange factor 7, Beta-Pix, COOL-1, PAK-interacting exchange factor beta, p85, ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Function Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.
Cellular Location Cell junction, focal adhesion. Cell projection, ruffle. Cytoplasm, cell cortex. Cell projection, lamellipodium Note=Detected at cell adhesions. A small proportion is detected at focal adhesions
Research Areas
Citations (0)

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Rho GTPases play a fundamental role in numerous cellularprocesses triggered by extracellular stimuli that work through Gprotein coupled receptors. The encoded protein belongs to a familyof cytoplasmic proteins that activate the Ras-like family of Rhoproteins by exchanging bound GDP for GTP. It forms a complex withthe small GTP binding protein Rac1 and recruits Rac1 to membraneruffles and to focal adhesions. This protein can induce membraneruffling. Multiple alternatively spliced transcript variantsencoding different isoforms have been described for this gene.


Hsu, Y.H., et al. Am. J. Pathol. 176(6):3050-3061(2010)Lee, J.S., et al. J. Biol. Chem. 285(11):8104-8113(2010)Hsu, R.M., et al. Mol. Biol. Cell 21(2):287-301(2010)Johnson, A.D., et al. Hum. Mol. Genet. 18(14):2700-2710(2009)Stolk, L., et al. Nat. Genet. 41(6):645-647(2009)

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Cat# BP12266b
Availability: Back Order
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