Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
ARHG7 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q14155 |
|---|---|
| Clone Names | 80220172 |
| Gene ID | 8874 |
|---|---|
| Other Names | Rho guanine nucleotide exchange factor 7, Beta-Pix, COOL-1, PAK-interacting exchange factor beta, p85, ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ARHGEF7 |
|---|---|
| Synonyms | COOL1, KIAA0142, P85SPR, PAK3BP, PIXB |
| Function | Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. |
| Cellular Location | Cell junction, focal adhesion. Cell projection, ruffle. Cytoplasm, cell cortex Cell projection, lamellipodium. Note=Detected at cell adhesions. A small proportion is detected at focal adhesions |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Rho GTPases play a fundamental role in numerous cellularprocesses triggered by extracellular stimuli that work through Gprotein coupled receptors. The encoded protein belongs to a familyof cytoplasmic proteins that activate the Ras-like family of Rhoproteins by exchanging bound GDP for GTP. It forms a complex withthe small GTP binding protein Rac1 and recruits Rac1 to membraneruffles and to focal adhesions. This protein can induce membraneruffling. Multiple alternatively spliced transcript variantsencoding different isoforms have been described for this gene.
References
Hsu, Y.H., et al. Am. J. Pathol. 176(6):3050-3061(2010)Lee, J.S., et al. J. Biol. Chem. 285(11):8104-8113(2010)Hsu, R.M., et al. Mol. Biol. Cell 21(2):287-301(2010)Johnson, A.D., et al. Hum. Mol. Genet. 18(14):2700-2710(2009)Stolk, L., et al. Nat. Genet. 41(6):645-647(2009)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Shipping Information
