|Other Names||Follistatin-related protein 3, Follistatin-like protein 3, Follistatin-related gene protein, FSTL3, FLRG|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.|
|Cellular Location||Isoform 1: Secreted.|
|Tissue Location||Expressed in a wide range of tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Follistatin-like 3 is a secreted glycoprotein of thefollistatin-module-protein family. It may have a role inleukemogenesis.
Miron, P., et al. Prenat. Diagn. 30(3):224-228(2010)Thadhani, R., et al. Diabetes Care 33(3):664-669(2010)Bloise, E., et al. BMC Cancer 9, 320 (2009) :Stamler, R., et al. J. Biol. Chem. 283(47):32831-32838(2008)Lara-Pezzi, E., et al. Endocrinology 149(11):5822-5827(2008)
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