|Other Names||Transforming growth factor beta-1, TGF-beta-1, Latency-associated peptide, LAP, TGFB1, TGFB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.|
|Cellular Location||Latency-associated peptide: Secreted, extracellular space, extracellular matrix|
|Tissue Location||Highly expressed in bone (PubMed:11746498, PubMed:17827158). Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA) (PubMed:11746498, PubMed:17827158). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage (PubMed:17827158).|
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Provided below are standard protocols that you may find useful for product applications.
TGFB1 is a member of the transforming growthfactor beta (TGFB) family of cytokines, which are multifunctionalpeptides that regulate proliferation, differentiation, adhesion,migration, and other functions in many cell types. Many cells haveTGFB receptors, and the protein positively and negatively regulatesmany other growth factors. The secreted protein is cleaved into alatency-associated peptide (LAP) and a mature TGFB1 peptide, and isfound in either a latent form composed of a TGFB1 homodimer, a LAPhomodimer, and a latent TGFB1-binding protein, or in an active formcomposed of a TGFB1 homodimer. The mature peptide may also formheterodimers with other TGFB family members. This gene isfrequently upregulated in tumor cells, and mutations in this generesult in Camurati-Engelmann disease.
Perez, A.B., et al. Hum. Immunol. 71(11):1135-1140(2010)Xu, Z., et al. Biochem. Biophys. Res. Commun. 401(3):376-381(2010)Bran, G.M., et al. Anticancer Res. 30(9):3459-3463(2010)Zauli, G., et al. Blood 80(12):3036-3043(1992)Wrana, J.L., et al. Cell 71(6):1003-1014(1992)
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