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TGFB1 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P01137
Clone Names 81205047
Peptide ID 81205047
Additional Information
Gene ID 7040
Other Names Transforming growth factor beta-1, TGF-beta-1, Latency-associated peptide, LAP, TGFB1, TGFB
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TGFB1 (HGNC:11766)
Synonyms TGFB
Function Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
Cellular Location Latency-associated peptide: Secreted, extracellular space, extracellular matrix
Tissue Location Highly expressed in bone (PubMed:11746498, PubMed:17827158). Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA) (PubMed:11746498, PubMed:17827158). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage (PubMed:17827158).
Research Areas
Citations (0)

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TGFB1 is a member of the transforming growthfactor beta (TGFB) family of cytokines, which are multifunctionalpeptides that regulate proliferation, differentiation, adhesion,migration, and other functions in many cell types. Many cells haveTGFB receptors, and the protein positively and negatively regulatesmany other growth factors. The secreted protein is cleaved into alatency-associated peptide (LAP) and a mature TGFB1 peptide, and isfound in either a latent form composed of a TGFB1 homodimer, a LAPhomodimer, and a latent TGFB1-binding protein, or in an active formcomposed of a TGFB1 homodimer. The mature peptide may also formheterodimers with other TGFB family members. This gene isfrequently upregulated in tumor cells, and mutations in this generesult in Camurati-Engelmann disease.


Perez, A.B., et al. Hum. Immunol. 71(11):1135-1140(2010)Xu, Z., et al. Biochem. Biophys. Res. Commun. 401(3):376-381(2010)Bran, G.M., et al. Anticancer Res. 30(9):3459-3463(2010)Zauli, G., et al. Blood 80(12):3036-3043(1992)Wrana, J.L., et al. Cell 71(6):1003-1014(1992)

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Cat# BP12348a
Availability: Back Order
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