|Other Names||Carbohydrate sulfotransferase 6, 282-, Corneal N-acetylglucosamine-6-O-sulfotransferase, C-GlcNAc6ST, hCGn6ST, Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-beta, GST4-beta, N-acetylglucosamine 6-O-sulfotransferase 5, GlcNAc6ST-5, Gn6st-5, CHST6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Mediates sulfation of keratan in cornea. Keratan sulfate plays a central role in maintaining corneal transparency. Acts on the non-reducing terminal GlcNAc of short and long carbohydrate substrates that have poly-N- acetyllactosamine structures.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed in cornea. Mainly expressed in brain. Also expressed in spinal cord and trachea|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is an enzyme thatcatalyzes the transfer of a sulfate group to the GlcNAc residues ofkeratan. Keratan sulfate helps maintain corneal transparency.Defects in this gene are a cause of macular corneal dystrophy(MCD).
Liu, Z., et al. Cornea 29(8):883-888(2010)Dastani, Z., et al. Eur. J. Hum. Genet. 18(3):342-347(2010)Dang, X., et al. Mol. Vis. 15, 700-705 (2009) :Birgani, S.A., et al. Mol. Vis. 15, 373-377 (2009) :Sultana, A., et al. Mol. Vis. 15, 319-325 (2009) :
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