|Other Names||Myosin-binding protein C, cardiac-type, Cardiac MyBP-C, C-protein, cardiac muscle isoform, MYBPC3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.|
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MYBPC3 encodes the cardiac isoform of myosin-bindingprotein C. Myosin-binding protein C is a myosin-associated proteinfound in the cross-bridge-bearing zone (C region) of A bands instriated muscle. MYBPC3, the cardiac isoform, is expressedexclussively in heart muscle. Regulatory phosphorylation of thecardiac isoform in vivo by cAMP-dependent protein kinase (PKA) uponadrenergic stimulation may be linked to modulation of cardiaccontraction. Mutations in MYBPC3 are one cause of familialhypertrophic cardiomyopathy.
Millat, G., et al. Clin. Chim. Acta 411 (23-24), 1983-1991 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Millat, G., et al. Eur J Med Genet 53(5):261-267(2010)Zimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010)Brion, M., et al. Ann. Clin. Lab. Sci. 40(3):285-289(2010)
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