RASSF10 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | A6NK89 |
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Other Accession | NP_001073990.2 |
Clone Names | 100309269 |
Gene ID | 644943 |
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Other Names | Ras association domain-containing protein 10, RASSF10 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RASSF10 |
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Function | Plays an important role in regulating embryonic neurogenesis. |
Cellular Location | Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=During interphase, predominantly cytoplasmic, although some nuclear staining in several tumor cell contexts. During prophase, observed at developing centrosomes. Displays persistent localization with centrosomally radiating microtubule bundles until late telophase. Associates with spindle poles particularly during metaphase and anaphase before relocating back to the cytoplasm |
Tissue Location | Expressed in brain. Tends to be down-regulated in astrocytic gliomas due to promoter methylation. Methylation occurs early in gliomagenesis and the extent of methylation parallels with higher glioma grades, so that methylation is observed in close to 70% WHO grade IV primary glioblastomas, but not in grade I astrocytomas |
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Provided below are standard protocols that you may find useful for product applications.
References
Schagdarsurengin, U., et al. Epigenetics 4(8):571-576(2009)Hesson, L.B., et al. Mol. Cancer 8, 42 (2009) :Sherwood, V., et al. Mol. Biol. Cell 19(4):1772-1782(2008)
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