|Other Names||[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial, PDP 1, Protein phosphatase 2C, Pyruvate dehydrogenase phosphatase catalytic subunit 1, PDPC 1, PDP1, PDP, PPM2C|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.|
|Cellular Location||Mitochondrion matrix.|
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Provided below are standard protocols that you may find useful for product applications.
Pyruvate dehydrogenase (E1) is one of the three components(E1, E2, and E3) of the large pyruvate dehydrogenase complex.Pyruvate dehydrogenase kinases catalyze phosphorylation of serineresidues of E1 to inactivate the E1 component and inhibit thecomplex. Pyruvate dehydrogenase phosphatases catalyze thedephosphorylation and activation of the E1 component to reverse theeffects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenasephosphatase is a heterodimer consisting of catalytic and regulatorysubunits. Two catalytic subunits have been reported; one ispredominantly expressed in skeletal muscle and another one is ismuch more abundant in the liver. The catalytic subunit, encoded bythis gene, is the former, and belongs to the protein phosphatase 2C(PP2C) superfamily. Along with the pyruvate dehydrogenase complexand pyruvate dehydrogenase kinases, this enzyme is located in themitochondrial matrix. Mutation in this gene causes pyruvatedehydrogenase phosphatase deficiency. Multiple alternativelyspliced transcript variants encoding different isoforms have beenidentified.
Kato, J., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (PT 3), 342-345 (2010) :Cameron, J.M., et al. Hum. Genet. 125(3):319-326(2009)Stellingwerff, T., et al. Am. J. Physiol. Endocrinol. Metab. 290 (2), E380-E388 (2006) :Maj, M.C., et al. J. Clin. Endocrinol. Metab. 90(7):4101-4107(2005)Piccinini, M., et al. Obes. Res. 13(4):678-686(2005)
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