|Other Names||Fas-activated serine/threonine kinase, FAST kinase, FASTK|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor.|
|Cellular Location||Isoform 4: Mitochondrion matrix. Note=Colocalizes with mitochondrial RNA granules.|
|Tissue Location||Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of theserine/threonine protein kinase family. This kinase was shown to beactivated rapidly during Fas-mediated apoptosis in Jurkat cells. Inresponse to Fas receptor ligation, it phosphorylates TIA1, anapoptosis-promoting nuclear RNA-binding protein. The encodedprotein is a strong inducer of lymphocyte apoptosis. Two transcriptvariants encoding different isoforms have been found for this gene.Other variants exist, but their full-length natures have not yetbeen determined.
Simarro, M., et al. J. Immunol. 184(9):5325-5332(2010)de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)Simarro, M., et al. Proc. Natl. Acad. Sci. U.S.A. 104(27):11370-11375(2007)Wu, C., et al. Proteomics 7(11):1775-1785(2007)Izquierdo, J.M., et al. J. Biol. Chem. 282(3):1539-1543(2007)
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