HYAL2 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q12891 |
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Clone Names | 100318037 |
Gene ID | 8692 |
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Other Names | Hyaluronidase-2, Hyal-2, Hyaluronoglucosaminidase-2, Lung carcinoma protein 2, LuCa-2, HYAL2, LUCA2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | HYAL2 |
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Synonyms | LUCA2 |
Function | Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R. |
Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor |
Tissue Location | Widely expressed. No expression detected in adult brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a weak acid-active hyaluronidase. Theencoded protein is similar in structure to other more activehyaluronidases. Hyaluronidases degrade hyaluronan, one of the majorglycosaminoglycans of the extracellular matrix. Hyaluronan andfragments of hyaluronan are thought to be involved in cellproliferation, migration and differentiation. Although it waspreviously thought to be a lysosomal hyaluronidase that is activeat a pH below 4, the encoded protein is likely a GPI-anchored cellsurface protein. This hyaluronidase serves as a receptor for theoncogenic virus Jaagsiekte sheep retrovirus. The gene is one ofseveral related genes in a region of chromosome 3p21.3 associatedwith tumor suppression. This gene encodes two alternatively splicedtranscript variants which differ only in the 5' UTR.
References
Monzon, M.E., et al. J. Biol. Chem. 285(34):26126-26134(2010)Tzuman, Y.C., et al. Neoplasia 12(1):51-60(2010)de la Motte, C., et al. Am. J. Pathol. 174(6):2254-2264(2009)Nykopp, T.K., et al. BMC Cancer 9, 143 (2009) :Miller, A.D., et al. Osteoarthr. Cartil. 14(12):1315-1317(2006)
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