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PC Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P11498 |
|---|---|
| Clone Names | 100318107 |
| Gene ID | 5091 |
|---|---|
| Other Names | Pyruvate carboxylase, mitochondrial, Pyruvic carboxylase, PCB, PC |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PC (HGNC:8636) |
|---|---|
| Function | Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. |
| Cellular Location | Mitochondrion matrix |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes pyruvate carboxylase, which requiresbiotin and ATP to catalyse the carboxylation of pyruvate tooxaloacetate. The active enzyme is a homotetramer arranged in atetrahedron which is located exclusively in the mitochondrialmatrix. Pyruvate carboxylase is involved in gluconeogenesis,lipogenesis, insulin secretion and synthesis of theneurotransmitter glutamate. Mutations in this gene have beenassociated with pyruvate carboxylase deficiency. Alternativelyspliced transcript variants with different 5' UTRs, but encodingthe same protein, have been found for this gene. [provided byRefSeq].
References
MacDonald, M.J., et al. Diabetologia 52(6):1087-1091(2009)Monnot, S., et al. Hum. Mutat. 30(5):734-740(2009)Wang, D., et al. Mol. Genet. Metab. 95 (1-2), 31-38 (2008) :Vora, S., et al. Natl Med J India 21(3):116-119(2008)Xiang, S., et al. Nat. Struct. Mol. Biol. 15(3):295-302(2008)
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