|Other Names||Tumor necrosis factor receptor superfamily member 16, Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, NGF receptor, p75 ICD, CD271, NGFR, TNFRSF16|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Nerve growth factor receptor contains an extracellulardomain containing four 40-amino acid repeats with 6 cysteineresidues at conserved positions followed by a serine/threonine-richregion, a single transmembrane domain, and a 155-amino acidcytoplasmic domain. The cysteine-rich region contains the nervegrowth factor binding domain.
Boiko, A.D., et al. Nature 466(7302):133-137(2010)Ceni, C., et al. J. Cell. Sci. 123 (PT 13), 2299-2307 (2010) :Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)Bosker, F.J., et al. Mol. Psychiatry (2010) In press :Sornelli, F., et al. Mol. Vis. 16, 1439-1447 (2010) :
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