|Other Names||ERBB receptor feedback inhibitor 1, Mitogen-inducible gene 6 protein, MIG-6, ERRFI1, MIG6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity).|
|Cellular Location||Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus Note=Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes (By similarity).|
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ERRFI1 is a cytoplasmic protein whose expression isupregulated with cell growth (Wick et al., 1995 [PubMed 7641805]).It shares significant homology with the protein product of ratgene-33, which is induced during cell stress and mediates cellsignaling (Makkinje et al., 2000 [PubMed 10749885]; Fiorentino etal., 2000 [PubMed 11003669]).
Frosi, Y., et al. J. Cell Biol. 189(3):557-571(2010)Ying, H., et al. Proc. Natl. Acad. Sci. U.S.A. 107(15):6912-6917(2010)Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)Reschke, M., et al. Hepatology 51(4):1383-1390(2010)Nagashima, T., et al. FEBS J. 276(18):5239-5251(2009)
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