PNKD Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8N490 |
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Clone Names | 100318161 |
Gene ID | 25953 |
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Other Names | Probable hydrolase PNKD, 3---, Myofibrillogenesis regulator 1, MR-1, Paroxysmal nonkinesiogenic dyskinesia protein, Trans-activated by hepatitis C virus core protein 2, PNKD, KIAA1184, MR1, TAHCCP2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PNKD |
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Synonyms | KIAA1184, MR1, TAHCCP2 |
Function | Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway. |
Cellular Location | [Isoform 1]: Membrane; Peripheral membrane protein [Isoform 3]: Mitochondrion. |
Tissue Location | Isoform 1 is only expressed in the brain. Isoform 2 is ubiquitously detected with highest expression in skeletal muscle and detected in myocardial myofibrils. Variant Val-7 and Val-9 are detected in the brain only. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is thought to play a role in the regulation ofmyofibrillogenesis. Mutations in this gene have been associatedwith the movement disorder paroxysmal non-kinesigenic dyskinesia.Alternative splicing results in multiple transcript variants.
References
Yang, J., et al. Neuron 66(6):871-883(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Ghezzi, D., et al. Hum. Mol. Genet. 18(6):1058-1064(2009)Friedman, A., et al. Eur. Neurol. 61(1):39-41(2009)Ren, K., et al. J. Biol. Chem. 283(51):35598-35605(2008)
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