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PNKD Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8N490 |
|---|---|
| Clone Names | 100318161 |
| Gene ID | 25953 |
|---|---|
| Other Names | Probable hydrolase PNKD, 3---, Myofibrillogenesis regulator 1, MR-1, Paroxysmal nonkinesiogenic dyskinesia protein, Trans-activated by hepatitis C virus core protein 2, PNKD, KIAA1184, MR1, TAHCCP2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PNKD |
|---|---|
| Synonyms | KIAA1184, MR1, TAHCCP2 |
| Function | Probable thioesterase that may play a role in cellular detoxification processes; it likely acts on a yet-unknown alpha- hydroxythioester substrate (Probable). In vitro, it is able to catalyze the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D- lactic acid at very low rate, though this reaction is not physiologically relevant in vivo (PubMed:21487022). |
| Cellular Location | [Isoform 1]: Cell membrane; Peripheral membrane protein. Mitochondrion [Isoform 3]: Mitochondrion. Golgi apparatus. Endoplasmic reticulum |
| Tissue Location | Isoform 1 is only expressed in the brain. Isoform 2 is ubiquitously detected with highest expression in skeletal muscle and detected in myocardial myofibrils. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is thought to play a role in the regulation ofmyofibrillogenesis. Mutations in this gene have been associatedwith the movement disorder paroxysmal non-kinesigenic dyskinesia.Alternative splicing results in multiple transcript variants.
References
Yang, J., et al. Neuron 66(6):871-883(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Ghezzi, D., et al. Hum. Mol. Genet. 18(6):1058-1064(2009)Friedman, A., et al. Eur. Neurol. 61(1):39-41(2009)Ren, K., et al. J. Biol. Chem. 283(51):35598-35605(2008)
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