|Other Names||Ceramide glucosyltransferase, GLCT-1, Glucosylceramide synthase, GCS, UDP-glucose ceramide glucosyltransferase, UDP-glucose:N-acylsphingosine D-glucosyltransferase, UGCG|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase".|
|Cellular Location||Golgi apparatus membrane; Multi-pass membrane protein|
|Tissue Location||Found in all tissues examined.|
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Provided below are standard protocols that you may find useful for product applications.
Glycosphingolipids (GSLs) are a group of membranecomponents that contain lipid and sugar moieties. They are presentin essentially all animal cells and are believed to have importantroles in various cellular processes. UDP-glucose ceramideglucosyltransferase catalyzes the first glycosylation step inglycosphingolipid biosynthesis. The product, glucosylceramide, isthe core structure of more than 300 GSLs. UGCG is widely expressedand transcription is upregulated during keratinocytedifferentiation.
Yang, G.Q., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27(3):299-304(2010)Ruckhaberle, E., et al. J. Cancer Res. Clin. Oncol. 135(1):81-90(2009)Xie, P., et al. Leuk. Res. 32(3):475-480(2008)Marks, N., et al. Brain Res. 1191, 136-147 (2008) :Fazi, B., et al. Biochem. Biophys. Res. Commun. 342(3):881-886(2006)
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