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NPHP3 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q7Z494
Clone Names 100324203
Peptide ID 100324203
Additional Information
Gene ID 27031
Other Names Nephrocystin-3, NPHP3, KIAA2000
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NPHP3
Synonyms KIAA2000
Function Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling which regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements.
Cellular Location Cell projection, cilium Note=Localization to cilium is mediated via interaction with UNC119 and UNC119B, which bind to the myristoyl moiety of the N- terminus
Tissue Location Widely expressed at low level. Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas Expressed at very low level in brain and lung
Research Areas
Citations (0)

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This gene encodes a protein containing a coiled-coil (CC)domain, a tubulin-tyrosine ligase (TTL) domain, and a tetratricopeptide repeat (TPR) domain. The encoded protein interacts withnephrocystin and may function in renal tubular development andfunction. Mutations in this gene are associated withnephronophthisis type 3. Multiple splice variants have beendescribed but their full-length nature has not been determined.


Simpson, M.A., et al. Am. J. Kidney Dis. 53(5):790-795(2009)Tory, K., et al. Kidney Int. 75(8):839-847(2009)Bergmann, C., et al. Am. J. Hum. Genet. 82(4):959-970(2008)Hoefele, J., et al. J. Am. Soc. Nephrol. 18(10):2789-2795(2007)Leipe, D.D., et al. J. Mol. Biol. 343(1):1-28(2004)

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Cat# BP12751a
Availability: Back Order
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