SPOPL Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q6IQ16 |
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Clone Names | 91201289 |
Gene ID | 339745 |
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Other Names | Speckle-type POZ protein-like, HIB homolog 2, Roadkill homolog 2, SPOPL |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SPOPL |
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Function | Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin- protein ligase complexes that contain SPOP. |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
In complex with a cullin, may act in ubiquitination and proteasomal degradation processes (By similarity).
References
Lamesch, P., et al. Genomics 89(3):307-315(2007)Zhang, Q., et al. Dev. Cell 10(6):719-729(2006)Kent, D., et al. Development 133(10):2001-2010(2006)
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