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SLC25A14 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O95258 |
|---|---|
| Clone Names | 100324198 |
| Gene ID | 9016 |
|---|---|
| Other Names | Brain mitochondrial carrier protein 1, BMCP-1, Mitochondrial uncoupling protein 5, UCP 5, Solute carrier family 25 member 14, SLC25A14, BMCP1, UCP5 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC25A14 (HGNC:10984) |
|---|---|
| Function | Transports inorganic anions (sulfate, sulfite, thiosulfate and phosphate) and, to a lesser extent, a variety of dicarboxylates (e.g. malonate, malate and citramalate) and, even more so, aspartate and glutamate and tricarboxylates (PubMed:31356773). May catalyze the export of sulfite and thiosulfate (the hydrogen sulfide degradation products) from the mitochondria, thereby modulating the level of the hydrogen sulfide (Probable). Also can mediate a very low unidirectional transport of anions including sulfate, phosphate, (S)-malate, citrate, L-aspartate and L-glutamate (PubMed:31356773). Maintains oxidative balance (through uncoupling activities) and ATP production (by modifying mitochondrial membrane potential) (PubMed:20600837). Is able to transport protons across lipid membranes (PubMed:22524567, PubMed:26182433). Also exhibits transmembrane chloride transport activity to a lesser extent(PubMed:22524567, PubMed:26182433). May modify mitochondrial respiratory efficiency and mitochondrial oxidant production (By similarity). |
| Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein |
| Tissue Location | Mainly expressed in brain (PubMed:10928996). Some expression in testis and pituitary (PubMed:10928996) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Mitochondrial uncoupling proteins (UCP) are members of thelarger family of mitochondrial anion carrier proteins (MACP). UCPsseparate oxidative phosphorylation from ATP synthesis with energydissipated as heat, also referred to as the mitochondrial protonleak. UCPs facilitate the transfer of anions from the inner to theouter mitochondrial membrane and the return transfer of protonsfrom the outer to the inner mitochondrial membrane. They alsoreduce the mitochondrial membrane potential in mammalian cells.Tissue specificity occurs for the different UCPs and the exactmethods of how UCPs transfer H+/OH- are not known. UCPs contain thethree homologous protein domains of MACPs. This gene is widelyexpressed in many tissues with the greatest abundance in brain andtestis. The gene product has an N-terminal hydrophobic domain thatis not present in other UCPs. Two splice variants have been foundfor this gene.
References
Santandreu, F.M., et al. Cell. Physiol. Biochem. 24 (5-6), 379-390 (2009) :Nakase, T., et al. Neuropathology 27(5):442-447(2007)Yasuno, K., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (2), 250-253 (2007) :Ho, P.W., et al. J. Neurosci. Res. 84(6):1358-1366(2006)Ross, M.T., et al. Nature 434(7031):325-337(2005)
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