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SP140 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q13342
Clone Names 101008149
Peptide ID 101008149
Additional Information
Gene ID 11262
Other Names Nuclear body protein SP140 {ECO:0000312|HGNC:HGNC:17133}, Lymphoid-restricted homolog of Sp100, LYSp100, Nuclear autoantigen Sp-140, Speckled 140 kDa, SP140 (HGNC:17133)
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SP140 (HGNC:17133)
Function Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body (PubMed:8910577). May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection (PubMed:8910577). May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails (PubMed:24267382).
Cellular Location Nucleus. Nucleus, PML body Cytoplasm. Note=Localized to nuclear structures termed LANDS, for LYSp100-associated nuclear domains LANDS are globular, electron-dense structures most often found in the nucleoplasm, but also found at the nuclear membrane and in the cytoplasm, suggesting that these structures may traffic between the cytoplasm and the nucleus (PubMed:8695863). Also colocalizes with PML in a subset of PML nuclear bodies (PubMed:8910577)
Tissue Location High levels in spleen and peripheral blood leukocytes, much lower levels in tonsils, thymus, prostate, ovary, small intestine, and colon (PubMed:8695863, PubMed:8910577.) Very low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas (PubMed:8910577). Not detected in brain, liver and muscle (PubMed:8695863)
Research Areas
Citations (0)

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Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection.


Slager, S.L., et al. Cancer Epidemiol. Biomarkers Prev. 19(4):1098-1102(2010)Di Bernardo, M.C., et al. Nat. Genet. 40(10):1204-1210(2008)Madani, N., et al. J. Virol. 76(21):11133-11138(2002)Bloch, D.B., et al. J. Biol. Chem. 271(46):29198-29204(1996)Dent, A.L., et al. Blood 88(4):1423-1426(1996)

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Cat# BP12872c
Availability: Back Order
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