Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
ENOX2 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q16206 |
|---|---|
| Clone Names | 100318147 |
| Gene ID | 10495 |
|---|---|
| Other Names | Ecto-NOX disulfide-thiol exchanger 2, APK1 antigen, Cytosolic ovarian carcinoma antigen 1, Tumor-associated hydroquinone oxidase, tNOX, Hydroquinone [NADH] oxidase, 1---, Protein disulfide-thiol oxidoreductase, 1---, ENOX2, COVA1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ENOX2 |
|---|---|
| Synonyms | COVA1 |
| Function | May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. |
| Cellular Location | Cell membrane. Secreted, extracellular space. Note=Extracellular and plasma membrane-associated |
| Tissue Location | Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Not found in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells. Found on the cell borders of renal, kidney and ovarian carcinomas but not on the borders of surrounding non- cancerous stromal cells |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a growth-related cellsurface protein. It was identifed because it reacts with themonoclonal antibody KI in cells, such as the ovarian carcinoma lineOVCAR-3, also expressing the CAKI surface glycoprotein. The encodedprotein has two enzymatic activities: catalysis of hydroquinone orNADH oxidation, and protein disulfide interchange. The twoactivities alternate with a period length of about 24 minutes. Theencoded protein also displays prion-like properties. Two transcriptvariants encoding different isoforms have been found for this gene.
References
Morre, D.M., et al. Rejuvenation Res 13 (2-3), 162-164 (2010) :Morre, D.M., et al. Biofactors 34(3):237-244(2009)Mao, L.C., et al. FEBS Lett. 582 (23-24), 3445-3450 (2008) :Liu, S.C., et al. Biochem. Biophys. Res. Commun. 365(4):672-677(2008)Tang, X., et al. Oncol. Res. 16(12):557-567(2007)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Shipping Information
