SIM1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P81133 |
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Clone Names | 100324039 |
Gene ID | 6492 |
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Other Names | Single-minded homolog 1, Class E basic helix-loop-helix protein 14, bHLHe14, SIM1, BHLHE14 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SIM1 |
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Synonyms | BHLHE14 |
Function | Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00632, ECO:0000255|PROSITE-ProRule:PRU00981} |
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Provided below are standard protocols that you may find useful for product applications.
Background
SIM1 and SIM2 genes are Drosophila single-minded (sim)gene homologs. SIM1 transcript was detected only in fetal kidneyout of various adult and fetal tissues tested. Since the sim geneplays an important role in Drosophila development and has peaklevels of expression during the period of neurogenesis,it wasproposed that the human SIM gene is a candidate for involvement incertain dysmorphic features (particularly the facial and skullcharacteristics), abnormalities of brain development, and/or mentalretardation of Down syndrome.
References
Ghoussaini, M., et al. Obesity (Silver Spring) 18(8):1670-1675(2010)Tolson, K.P., et al. J. Neurosci. 30(10):3803-3812(2010)Traurig, M., et al. Diabetes 58(7):1682-1689(2009)Gregorio, S.P., et al. Psychiatry Res 165 (1-2), 1-9 (2009) :Hung, C.C., et al. Int J Obes (Lond) 31(3):429-434(2007)
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