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MBTPS2 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O43462
Clone Names 100324186
Peptide ID 100324186
Additional Information
Gene ID 51360
Other Names Membrane-bound transcription factor site-2 protease, Endopeptidase S2P, Sterol regulatory element-binding proteins intramembrane protease, SREBPs intramembrane protease, MBTPS2, S2P
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms S2P
Function Involved in regulated intramembrane proteolysis (RIP) that is the cleavage of membrane-spanning regulatory proteins by proteases within the plane of the membrane. It cleaves sterol- regulatory element-binding proteins (SREBPs) within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N- terminal fragments shuttle to the nucleus and activate gene transcription (PubMed:9659902, PubMed:27380894). Involved in RIP- mediated regulation of bone formation (PubMed:27380894).
Cellular Location Membrane; Multi-pass membrane protein Cytoplasm
Tissue Location Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas.
Research Areas
Citations (0)

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This gene encodes a intramembrane zinc metalloprotease,which is essential in development. This protease functions in thesignal protein activation involved in sterol control oftranscription and the ER stress response. Mutations in this genehave been associated with ichthyosis follicularis with atrichia andphotophobia (IFAP syndrome); IFAP syndrome has been quantitativelylinked to a reduction in cholesterol homeostasis and ER stressresponse.


Ming, A., et al. Pediatr Dermatol 26(4):427-431(2009)Oeffner, F., et al. Am. J. Hum. Genet. 84(4):459-467(2009)Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)Shen, J., et al. J. Biol. Chem. 279(41):43046-43051(2004)Lee, K., et al. Genes Dev. 16(4):452-466(2002)

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Cat# BP12972a
Availability: Back Order
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