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SLC6A14 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UN76 |
|---|---|
| Clone Names | 100324216 |
| Gene ID | 11254 |
|---|---|
| Other Names | Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+), Amino acid transporter ATB0+, Solute carrier family 6 member 14, SLC6A14 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC6A14 (HGNC:11047) |
|---|---|
| Function | Amino acid transporter that plays an important role in the absorption of amino acids in the intestinal tract. Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner (PubMed:10446133). Transports non-alpha-amino acids such as beta- alanine with low affinity, and has a higher affinity for dipolar and cationic amino acids such as leucine and lysine (PubMed:18599538). Can also transport carnitine, butirylcarnitine and propionylcarnitine coupled to the transmembrane gradients of Na(+) and Cl(-) (PubMed:17855766). |
| Cellular Location | Membrane; Multi- pass membrane protein. Apical cell membrane {ECO:0000250|UniProtKB:Q9JMA9}; Multi-pass membrane protein |
| Tissue Location | Levels are highest in adult and fetal lung, in trachea and salivary gland. Lower levels detected in mammary gland, stomach and pituitary gland, and very low levels in colon, uterus, prostate and testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the solute carrier family 6.Members of this family are sodium and chloride dependentneurotransmitter transporters. The encoded protein transports bothneutral and cationic amino acids. This protein may also function asa beta-alanine carrier. Mutations in this gene may be associatedwith X-linked obesity. A pseudogene of this gene is found onchromosome X.
References
Bailey, S.D., et al. Diabetes Care (2010) In press :Corpeleijn, E., et al. Obesity (Silver Spring) 18(7):1369-1377(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Anderson, C.M., et al. J. Physiol. (Lond.) 586 (PT 17), 4061-4067 (2008) :Eriksson, A., et al. BMC Gastroenterol 8, 34 (2008) :
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